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The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmia

Two models of the aconitin-induced cardiac arrhythmias were used to compare the antiarrhythmic and antifibrillatory activity of the reference drug Lappaconitine hydrobromide and the LMG-124 compound. It is shown that both compounds have antiarrhythmic action. At the same time, the compound LMG-124 r...

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Main Authors: V. N. Stolyaruk (Author), I. B. Tsorin (Author), M. B. Vititnova (Author), T. D. Nikiforova (Author), Yu. I. Murinov (Author), M. S. Yunusov (Author), S. A. Kryzhanovskii (Author)
Format: Book
Published: LLC "Publisher OKI", 2017-03-01T00:00:00Z.
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Summary:Two models of the aconitin-induced cardiac arrhythmias were used to compare the antiarrhythmic and antifibrillatory activity of the reference drug Lappaconitine hydrobromide and the LMG-124 compound. It is shown that both compounds have antiarrhythmic action. At the same time, the compound LMG-124 realizes its antiarrhythmic effect in a significantly lower dose. In this case, the compound LMG-124 shows a pronounced antifibrillatory activity, in contrast to the reference drug Lappaconitine hydrobromide, which in the studied dose does not exhibit similar activity.
Item Description:2587-7836
2686-8830

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