Use of rodents as models of human diseases

Advances in molecular biology have significantly increased the understanding of the biology of different diseases. However, these discoveries have not yet been fully translated into improved treatments for patients with diseases such as cancers. One of the factors limiting the translation of knowled...

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Bibliographic Details
Main Author: Thierry F Vandamme (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2014-01-01T00:00:00Z.
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100 1 0 |a Thierry F Vandamme  |e author 
245 0 0 |a Use of rodents as models of human diseases 
260 |b Wolters Kluwer Medknow Publications,   |c 2014-01-01T00:00:00Z. 
500 |a 0975-7406 
500 |a 0976-4879 
500 |a 10.4103/0975-7406.124301 
520 |a Advances in molecular biology have significantly increased the understanding of the biology of different diseases. However, these discoveries have not yet been fully translated into improved treatments for patients with diseases such as cancers. One of the factors limiting the translation of knowledge from preclinical studies to the clinic has been the limitations of in vivo diseases models. In this brief review, we will discuss the advantages and disadvantages of rodent models that have been developed to simulate human pathologies, focusing in models that employ xenografts and genetic modification. Within the framework of genetically engineered mouse (GEM) models, we will review some of the current genetic strategies for modeling diseases in the mouse and the preclinical studies that have already been undertaken. We will also discuss how recent improvements in imaging technologies may increase the information derived from using these GEMs during early assessments of potential therapeutic pathways. Furthermore, it is interesting to note that one of the values of using a mouse model is the very rapid turnover rate of the animal, going through the process of birth to death in a very short timeframe relative to that of larger mammalian species. 
546 |a EN 
690 |a Cancer 
690 |a genetically modified animals 
690 |a human diseases 
690 |a rodents 
690 |a transgenic 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
690 |a Analytical chemistry 
690 |a QD71-142 
655 7 |a article  |2 local 
786 0 |n Journal of Pharmacy and Bioallied Sciences, Vol 6, Iss 1, Pp 2-9 (2014) 
787 0 |n http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2014;volume=6;issue=1;spage=2;epage=9;aulast=Vandamme 
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787 0 |n https://doaj.org/toc/0976-4879 
856 4 1 |u https://doaj.org/article/0c33c308d6e84bfcbc78f92c0d4dba6b  |z Connect to this object online.