Genetically engineered animal models for Marfan syndrome: challenges associated with the generation of pig models for diseases caused by haploinsufficiency

• Hlavní autoři: Naomi JACK (Autor), Tomoyuki MUTO (Autor), Keigo IEMITSU (Autor), Tamaki WATANABE (Autor), Kazuhiro UMEYAMA (Autor), Jun OHGANE (Autor), Hiroshi NAGASHIMA (Autor)
• Médium: Kniha
• Vydáno: The Society for Reproduction and Development, 2022-05-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Recent developments in reproductive biology have enabled the generation of genetically engineered pigs as models for inherited human diseases. Although a variety of such models for monogenic diseases are currently available, reproduction of human diseases caused by haploinsufficiency remains a major...