Synthesis and COX-2 Inhibitory Activity of 4-[(E)-2-(4-Oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethenyl]benzene-1-sulfonamide and Its Analogs

• Autori principali: Hayun (Autore), Sumi Hudiyono (Autore), Muhammad Hanafi (Autore), Arry Yanuar (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2012-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Some novel 3-phenyl-2-[(E)-2-phenylethenyl]-3,4-dihydroquinazolin-4-one derivatives possessing para-sulfonamides groups on the phenyl ring of the 2-phenylethenyl moiety have been synthesized and their COX-2 inhibitory activity evaluated. The stuctures of the synthesized compounds were confirmed&...