Evaluation of possible mechanisms of three plants for blood glucose control in diabetes
This study was conducted to provide the evidence for the mechanism of anti-diabetic activity of Cocculus orbiculatus, Leea indica and Ventilago maderaspatana. This was accomplished by employing methods like uptake of glucose, glycogen synthesis and inhibition of ?-glucosidase. For uptake of glucose...
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| Main Authors: | , |
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| Format: | Book |
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Bangladesh Pharmacological Society,
2016-01-01T00:00:00Z.
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| Summary: | This study was conducted to provide the evidence for the mechanism of anti-diabetic activity of Cocculus orbiculatus, Leea indica and Ventilago maderaspatana. This was accomplished by employing methods like uptake of glucose, glycogen synthesis and inhibition of ?-glucosidase. For uptake of glucose, diaphragms were dissected out in Tyrode solution with 2% glucose and assayed for glucose content. In glycogen synthesis methodology liver, skeletal muscle and cardiac muscles were isolated, homogenized and glycogen content was analyzed. In ?-glucosidase enzyme inhibition procedure involved estimation of ?-glucosidase enzyme inhibition. All the three plant extracts exhibited significant (p<0.05 - p<0.01) anti-diabetic activity by increasing glucose uptake, glycogen synthesis and inhibiting ?-glucosidase enzyme. Among the three plants, V. maderaspatana (500 mg/kg) exhibited higher glucose uptake, glycogen content and ?-glucosidase inhibition activity (IC50 145 µg/mL). The present experimental results evidenced the anti-diabetic activity of three plants by all the three mechanisms. |
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| Item Description: | 10.3329/bjp.v11i1.24932 1991-0088 |