Consanguineous familial study revealed biallelic FIGLA mutation associated with premature ovarian insufficiency

• Main Authors: Beili Chen (Author), Lin Li (Author), Jing Wang (Author), Tengyan Li (Author), Hong Pan (Author), Beihong Liu (Author), Yiran Zhou (Author), Yunxia Cao (Author), Binbin Wang (Author)
• Format: Book
• Published: BMC, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background To dissect the genetic alteration in two sisters with premature ovarian insufficiency (POI) from a consanguineous family. Methods Whole-exome sequencing technology was used in the POI proband, bioinformatics analysis was carried out to identify the potential genetic cause in this...