The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration
mRNA-lipoplex vaccines are currently being explored in phase II clinical trials for the treatment of patients with advanced solid tumors. Mechanistically, these mRNA-lipoplex vaccines are characterized by the induction of type I interferon (IFN) centered innate responses. Earlier studies have identi...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2020-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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