The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

• Main Authors: Lien Van Hoecke (Author), Kenny Roose (Author), Marlies Ballegeer (Author), Zifu Zhong (Author), Niek N. Sanders (Author), Stefaan De Koker (Author), Xavier Saelens (Author), Sandra Van Lint (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

mRNA-lipoplex vaccines are currently being explored in phase II clinical trials for the treatment of patients with advanced solid tumors. Mechanistically, these mRNA-lipoplex vaccines are characterized by the induction of type I interferon (IFN) centered innate responses. Earlier studies have identi...