The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats

• Main Authors: Francisco V. Souza-Neto (Author), Sara Jiménez-González (Author), Beatriz Delgado-Valero (Author), Raquel Jurado-López (Author), Marie Genty (Author), Ana Romero-Miranda (Author), Cristina Rodríguez (Author), María Luisa Nieto (Author), Ernesto Martínez-Martínez (Author), Victoria Cachofeiro (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have evaluated the role of mitochondrial oxidative stress and its association with endoplasmic reticulum (ER) stress activation in the progression of obesity-related cardiovascular fibrosis. MitoQ (200 µM) was orally administered for 7 weeks to male Wistar rats that were fed a high-fat diet (HFD,...