A Differentiated Approach to the Prescription of Antihistamines in Allergic Diseases in Childhood
The comparative analysis of current data on pharmacodynamics, pharmacokinetics, clinical efficacy and side effects of the first generation drug antihistamine demetinden and the third-generation levocetirizinum is presented. Levocetirizinum shows the highest selectivity to H1-receptor having antagon...
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| Main Authors: | , |
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| Format: | Book |
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Zaslavsky O.Yu.,
2016-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | The comparative analysis of current data on pharmacodynamics, pharmacokinetics, clinical efficacy and side effects of the first generation drug antihistamine demetinden and the third-generation levocetirizinum is presented. Levocetirizinum shows the highest selectivity to H1-receptor having antagonist properties does not penetrate the central nervous system and has no sedative effects. The drug has anti-inflammatory effects due to suppression of release of inflammation mediators and cellular response. Levocetirizinum has favorable pharmacokinetics and half-life, no drug interactions. The clinical studies demonstrated its high efficiency in ruducing the symptoms of allergic diseases. |
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| Item Description: | 2224-0551 2307-1168 10.22141/2224-0551.5.73.2016.78309 |