Polymer Distribution and Mechanism Conversion in Multiple Media of Phase-Separated Controlled-Release Film-Coating

• Main Authors: Lu Chen (Author), Guobao Yang (Author), Xiaoyang Chu (Author), Chunhong Gao (Author), Yuli Wang (Author), Wei Gong (Author), Zhiping Li (Author), Yang Yang (Author), Meiyan Yang (Author), Chunsheng Gao (Author)
• Format: Book
• Published: MDPI AG, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phase-separated films of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC) can be utilized to tailor drug release from coated pellets. In the present study, the effects of HPC levels and the pH, type, ionic strength and osmolarity of the media on the release profil...