Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents
The novel kojic acid derivatives KAD1 and KAD2 have been demonstrated that they exhibited potent anti-melanogenesis activity in our previous report. In this study, we further study the inhibitory mechanism on mushroom tyrosinase. The inhibitory types of both KADs on diphenolase were classified as mi...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Taylor & Francis Group,
2019-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_0e21e9d27f4744fc848fb461db87fc9f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yan-Mei Chen |e author |
| 700 | 1 | 0 | |a Chen Li |e author |
| 700 | 1 | 0 | |a Wen-Jing Zhang |e author |
| 700 | 1 | 0 | |a Yan Shi |e author |
| 700 | 1 | 0 | |a Zi-Jie Wen |e author |
| 700 | 1 | 0 | |a Qing-Xi Chen |e author |
| 700 | 1 | 0 | |a Qin Wang |e author |
| 245 | 0 | 0 | |a Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents |
| 260 | |b Taylor & Francis Group, |c 2019-01-01T00:00:00Z. | ||
| 500 | |a 1475-6366 | ||
| 500 | |a 1475-6374 | ||
| 500 | |a 10.1080/14756366.2019.1609467 | ||
| 520 | |a The novel kojic acid derivatives KAD1 and KAD2 have been demonstrated that they exhibited potent anti-melanogenesis activity in our previous report. In this study, we further study the inhibitory mechanism on mushroom tyrosinase. The inhibitory types of both KADs on diphenolase were classified as mixed type based on the results of the kinetic model. The interaction between KADs and tyrosinase was illustrated by fluorescence quenching, molecular docking and copper chelate activity. The KADs were also evaluated with respect to their antioxidant activities by DPPH and ABTS+ assays. The results showed that KADs have more potent antioxidant activities than kojic acid. Our study could provide new ideas for the development of new anti-tyrosinase and antioxidant agents. | ||
| 546 | |a EN | ||
| 690 | |a kojic acid derivatives | ||
| 690 | |a tyrosinase inhibition | ||
| 690 | |a antioxidant | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 990-998 (2019) | |
| 787 | 0 | |n http://dx.doi.org/10.1080/14756366.2019.1609467 | |
| 787 | 0 | |n https://doaj.org/toc/1475-6366 | |
| 787 | 0 | |n https://doaj.org/toc/1475-6374 | |
| 856 | 4 | 1 | |u https://doaj.org/article/0e21e9d27f4744fc848fb461db87fc9f |z Connect to this object online. |