In Silico Analysis of Novel Titin Non-Synonymous Missense Variants Detected by Targeted Next-Generation Sequencing in a Cohort of Romanian Index Patients with Hypertrophic Cardiomyopathy

• Huvudupphovsmän: Miruna Mihaela MICHEU (Författare, medförfattare), Nicoleta OPRESCU (Författare, medförfattare), Nicoleta-Monic (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Sciendo, 2021-09-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

Background and aim: Most of detected variants in cardiogenetic panels are still classified as variants of unknown significance, requiring supplementary analyses for a definite classification. Performing further in-depth studies on such vast number of candidates is unfeasible. We sought to prioritise...