Human intestinal epithelial and smooth muscle cells are potent producers of IL-6
Background: Interleukin-6 (IL-6), a pluripotent cytokine, has traditionally been considered the product of proinflammatory cells. However, many other cell types have been shown to produce IL-6. Since intestinal inflammation is commonly associated with a vigorous systemic inflammatory response, we hy...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Hindawi Limited,
2003-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Background: Interleukin-6 (IL-6), a pluripotent cytokine, has traditionally been considered the product of proinflammatory cells. However, many other cell types have been shown to produce IL-6. Since intestinal inflammation is commonly associated with a vigorous systemic inflammatory response, we hypothesized that intestinal epithelial and smooth muscle cells might contribute to that response by producing IL-6. We therefore studied the capacity of differentiated human intestinal epithelial and smooth muscle cell lines to produce IL-6 in response to various proinflammatory stimuli. |
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| Item Description: | 0962-9351 1466-1861 10.1080/0962935031000096917 |