Chemical Variations on the p53 Reactivation Theme

• Main Authors: Carlos J. A. Ribeiro (Author), Cecília M. P. Rodrigues (Author), Rui Moreira (Author), Maria M. M. Santos (Author)
• Format: Book
• Published: MDPI AG, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among the tumor suppressor genes, p53 is one of the most studied. It is widely regarded as the "guardian of the genome", playing a major role in carcinogenesis. In fact, direct inactivation of the TP53 gene occurs in more than 50% of malignancies, and in tumors that retain wild-type p53 st...