Focused Ultrasound-Enhanced Delivery of Intranasally Administered Anti-Programmed Cell Death-Ligand 1 Antibody to an Intracranial Murine Glioma Model

• Main Authors: Dezhuang Ye (Author), Jinyun Yuan (Author), Yimei Yue (Author), Joshua B. Rubin (Author), Hong Chen (Author)
• Formato: Libro
• Publicado: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Immune checkpoint inhibitors have great potential for the treatment of gliomas; however, their therapeutic efficacy has been partially limited by their inability to efficiently cross the blood-brain barrier (BBB). The objective of this study was to evaluate the capability of focused-ultrasound-media...