Sirtuin 3 Dependent and Independent Effects of NAD⁺ to Suppress Vascular Inflammation and Improve Endothelial Function in Mice

• Main Authors: Xiaoyun Cao (Author), Yalan Wu (Author), Huiling Hong (Author), Xiao Yu Tian (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atherosclerosis is initiated by endothelial cell dysfunction and vascular inflammation under the condition of hyperlipidemia. Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD⁺)-dependent mitochondrial deacetylase, which plays a key role in maintaining normal mitoc...