C3a and Its Receptor C3aR Are Detectable in Normal Human Epidermal Keratinocytes and Are Differentially Regulated via TLR3 and LL37

• Main Authors: Susanne Mommert (Author), Lisa Doenni (Author), Phillip Szudybill (Author), Christoph Zoeller (Author), Frerk Hinnerk Beyer (Author), Thomas Werfel (Author)
• Format: Book
• Published: Karger Publishers, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To study the molecular interplay between TLRs and complement representing ancient danger-sensing mechanisms, we examined the regulation of the C3a/anaphylatoxin C3a receptor (C3aR) axis in normal human epidermal keratinocytes (NHEKs) by treatment with different TLR ligands. Protein staining followed...