Schistosoma mansoni Infection in Ugandan Men Is Associated with Increased Abundance and Function of HIV Target Cells in Blood, but Not the Foreskin: A Cross-sectional Study.

• Main Authors: Jessica L Prodger (Author), Aloysious Ssemaganda (Author), Ali Ssetaala (Author), Paul K Kitandwe (Author), Enoch Muyanja (Author), Juliet Mpendo (Author), Annet Nanvubya (Author), Mathias Wambuzi (Author), Leslie Nielsen (Author), Noah Kiwanuka (Author), Rupert Kaul (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Schistosoma mansoni infection has been associated with an increased HIV prevalence in humans and SHIV incidence in primate models. We hypothesized that immune activation from this gastrointestinal mucosa infection would increase highly HIV-susceptible CD4 T cell subsets in the blood and t...