Optimization of dose and route of administration of the P‐glycoprotein inhibitor, valspodar (PSC‐833) and the P‐glycoprotein and breast cancer resistance protein dual‐inhibitor, elacridar (GF120918) as dual infusion in rats

• Hauptverfasser: Christopher Rowbottom (Verfasst von), Alicia Pietrasiewicz (Verfasst von), Taras Tuczewycz (Verfasst von), Richard Grater (Verfasst von), Daniel Qiu (Verfasst von), Sudarshan Kapadnis (Verfasst von), Patrick Trapa (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2021-04-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess the impact of transporters in vivo invol...