Optimization of dose and route of administration of the P‐glycoprotein inhibitor, valspodar (PSC‐833) and the P‐glycoprotein and breast cancer resistance protein dual‐inhibitor, elacridar (GF120918) as dual infusion in rats

• मुख्य लेखकों: Christopher Rowbottom (लेखक), Alicia Pietrasiewicz (लेखक), Taras Tuczewycz (लेखक), Richard Grater (लेखक), Daniel Qiu (लेखक), Sudarshan Kapadnis (लेखक), Patrick Trapa (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2021-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess the impact of transporters in vivo invol...