Optimization of dose and route of administration of the P‐glycoprotein inhibitor, valspodar (PSC‐833) and the P‐glycoprotein and breast cancer resistance protein dual‐inhibitor, elacridar (GF120918) as dual infusion in rats

Abstract Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess the impact of transporters in vivo invol...

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Principais autores: Christopher Rowbottom (Autor), Alicia Pietrasiewicz (Autor), Taras Tuczewycz (Autor), Richard Grater (Autor), Daniel Qiu (Autor), Sudarshan Kapadnis (Autor), Patrick Trapa (Autor)
Formato: Livro
Publicado em: Wiley, 2021-04-01T00:00:00Z.
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3rd Floor Main Library

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Número de Chamada: A1234.567
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