Optimization of dose and route of administration of the P‐glycoprotein inhibitor, valspodar (PSC‐833) and the P‐glycoprotein and breast cancer resistance protein dual‐inhibitor, elacridar (GF120918) as dual infusion in rats

• Главные авторы: Christopher Rowbottom (Автор), Alicia Pietrasiewicz (Автор), Taras Tuczewycz (Автор), Richard Grater (Автор), Daniel Qiu (Автор), Sudarshan Kapadnis (Автор), Patrick Trapa (Автор)
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• Опубликовано: Wiley, 2021-04-01T00:00:00Z.
• Предметы: article
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Abstract Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess the impact of transporters in vivo invol...