Optimization of dose and route of administration of the P‐glycoprotein inhibitor, valspodar (PSC‐833) and the P‐glycoprotein and breast cancer resistance protein dual‐inhibitor, elacridar (GF120918) as dual infusion in rats

• Những tác giả chính: Christopher Rowbottom (Tác giả), Alicia Pietrasiewicz (Tác giả), Taras Tuczewycz (Tác giả), Richard Grater (Tác giả), Daniel Qiu (Tác giả), Sudarshan Kapadnis (Tác giả), Patrick Trapa (Tác giả)
• Định dạng: Sách
• Được phát hành: Wiley, 2021-04-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Abstract Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess the impact of transporters in vivo invol...