Metronomic Four-Drug Regimen Has Anti-tumor Activity in Pediatric Low-Grade Glioma; The Results of a Phase II Clinical Trial

• Main Authors: Arnauld Verschuur (Author), Marie-Améli (Author), Philippe Dory-Lautrec (Author), Romain Truillet (Author), Elisabeth Jouve (Author), Pascal Chastagner (Author), Pierre Leblond (Author), Isabelle Aerts (Author), Stéphane Honoré (Author), Natasha Entz-Werle (Author), Nicolas Sirvent (Author), Jean-Claude Gentet (Author), Nadège Corradini (Author), Nicolas André (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Metronomic chemotherapy (MC) is defined as the frequent administration of chemotherapy at doses below the maximal tolerated dose and with no prolonged drug-free break. MC has shown its efficacy in adult tumor types such as breast and ovarian cancer and has to some extent been studied in...