Cover Image

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

Objective: Recently, we have shown that Bezafibrate (BEZ), the pan-PPAR (peroxisome proliferator-activated receptor) activator, ameliorated diabetes in insulin deficient streptozotocin treated diabetic mice. In order to study whether BEZ can also improve glucose metabolism in a mouse model for fatty...

Full description

Saved in:

Bibliographic Details
Main Authors:	Andras Franko (Author), Susanne Neschen (Author), Jan Rozman (Author), Birgit Rathkolb (Author), Michaela Aichler (Author), Annette Feuchtinger (Author), Laura Brachthäuser (Author), Frauke Neff (Author), Marketa Kovarova (Author), Eckhard Wolf (Author), Helmut Fuchs (Author), Hans-Ulrich Häring (Author), Andreas Peter (Author), Martin Hrabě de Angelis (Author)
Format:	Book
Published:	Elsevier, 2017-03-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Coadministration of Compound Danshen dripping pills and bezafibrate has a protective effect against diabetic retinopathy
by: Le Liu, et al.
Published: (2022)

Chemical degradation kinetics of fibrates: bezafibrate, ciprofibrate and fenofibrate
by: Marcelo Antonio de Oliveira, et al.

Chapter Tally sticks as media of knowledge in the contexts of medieval economic and administrative histor
by: Skambraks, Tanja
Published: (2023)

Chapter Tally sticks as media of knowledge in the contexts of medieval economic and administrative histor
by: Skambraks, Tanja
Published: (2023)

Population, economic and geographic predictors of nations' medal tallies at the Pyeongchang and Tokyo Olympics and Paralympics
by: Feifei Li, et al.
Published: (2022)

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis
by: Yin Q, et al.
Published: (2015)

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis [Erratum]
by: Yin Q, et al.
Published: (2015)

Bezafibrate Exerts Neuroprotective Effects in a Rat Model of Sporadic Alzheimer's Disease
by: Li-Fan Lin, et al.
Published: (2022)

A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα
by: Alessandra Ammazzalorso, et al.
Published: (2024)

Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats
by: Brian D. Fink, et al.
Published: (2021)

A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments
by: Xiao-Hua Li, et al.
Published: (2023)

Relationship between breastfeeding and hepatic steatosis in women with previous gestational diabetes mellitus
by: Supatsri Sethasine, et al.
Published: (2024)

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model
by: Bachuki Shashikadze, et al.
Published: (2023)

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus
by: Mattias Backman, et al.
Published: (2019)

The Impact of an SGLT2 Inhibitor versus Ursodeoxycholic Acid on Liver Steatosis in Diabetic Patients
by: Sahar H. Elhini, et al.
Published: (2022)

Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats
by: Malgorzata Elzbieta Knapik-Czajka
Published: (2015)

The Beneficial Additive Effect of Silymarin in Metformin Therapy of Liver Steatosis in a Pre-Diabetic Model
by: Martina Hüttl, et al.
Published: (2021)

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis
by: Emre E. Turer, et al.
Published: (2018)

HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosis
by: Behrang Motamed, et al.
Published: (2022)

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
by: Susanne Keipert, et al.
Published: (2015)

Analyzing Injury Patterns in Climbing: A Comprehensive Study of Risk Factors
by: Markéta Kovářová, et al.
Published: (2024)

Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes
by: Yasuhiro Hayashi, et al.
Published: (2014)

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes
by: Nirav Florian Chhabra, et al.
Published: (2021)

Regional fat distribution and hepatic fibrosis and steatosis severity in patients with nonalcoholic fatty liver disease and type 2 diabetes
by: Asieh Mansour, et al.
Published: (2024)

Nox4 Maintains Blood Pressure during Low Sodium Diet
by: Flávia Rezende, et al.
Published: (2021)

Inflammatory Mediators of Hepatic Steatosis
by: Elizabeth Hijona, et al.
Published: (2010)

L-Carnosine Stimulation of Coenzyme Q10 Biosynthesis Promotes Improved Mitochondrial Function and Decreases Hepatic Steatosis in Diabetic Conditions
by: Cheng Schwank-Xu, et al.
Published: (2021)

Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state
by: Philipp Schommers, et al.
Published: (2017)

Real Life In London, Volumes I. and II. Or, The Rambles and Adventures of Bob Tallyho, Esq., and His Cousin, the Hon. Tom Dashall, Through the Metropolis; Exhibiting a Living Picture of Fashionable Characters, Manners, and Amusements in High and Low Life (1821)
by: Badcock, John, active 1816-1830; Egan, Pierce, 1772-1849; Alken, Henry Thomas, 1784-1851 [Illustrator]; Dighton, Richard, 1795-1880 [Illustrator]; Heath, William, 1795-1840 [Illustrator]; Rowlandson, Thomas, 1756-1827 [Illustrator]

Liver steatosis as a predictor of incident diabetes in adults: a prospective evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
by: Luciana Costa Faria, et al.
Published: (2023)

Treatment with a Catalytic Superoxide Dismutase (SOD) Mimetic Improves Liver Steatosis, Insulin Sensitivity, and Inflammation in Obesity-Induced Type 2 Diabetes
by: Gina M. Coudriet, et al.
Published: (2017)

Mechanisms of hepatic steatosis formation in adolescent boys with hypoandrogenism
by: L.K. Parkhomenko, et al.
Published: (2021)

Prevalence of hepatic steatosis in women with polycystic ovary syndrome
by: Ritu Karoli, et al.
Published: (2013)

Stress kinases in the development of liver steatosis and hepatocellular carcinoma
by: Beatriz Cicuéndez, et al.
Published: (2021)

Resveratrol Metabolites Are Able to Reduce Steatosis in Cultured Hepatocytes
by: Jenifer Trepiana, et al.
Published: (2020)

Risk Factors for Liver Steatosis in Obese Children and Adolescents
by: Yu-Cheng Lin, et al.
Published: (2010)

Automated quantification of steatosis: agreement with stereological point counting
by: André Homeyer, et al.
Published: (2017)

Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model
by: Evamaria O. Riedel, et al.
Published: (2020)

Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats
by: Carlos Torrado-Salmerón, et al.
Published: (2021)

Biochemical Markers of Lipid Metabolism Disorders in Children with Hepatic Steatosis
by: N.Yu. Zavhorodnia, et al.
Published: (2015)