A Difficult Case of Ventriculitis in a 40-Year-Old Woman with Acute Myeloid Leukemia

• Main Authors: Raffaella Rubino (Author), Marcello Trizzino (Author), Luca Pipitò (Author), Giuseppe Sucato (Author), Marco Santoro (Author), Rosario Maugeri (Author), Domenico Gerardo Iacopino (Author), Giovanni Maurizio Giammanco (Author), Sergio Siragusa (Author), Antonio Cascio (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing <i>Klebsiella pneumoniae</i> and vancomycin-resistant <i>Enterococcus faecium</i> in a young woman with acute leukemia who was successfully treated with meropenem/vaborbactam (MVB), rifampicin, and linezolid is described in this paper. This case report emphasizes the importance of a multidisciplinary strategy, including infectious focus control, for the treatment of device-associated central nervous system (CNS) infections from multidrug-resistant bacteria. Considering the novel resistance patterns, more research on drug penetration into the central nervous system, as well as on the necessity of association therapies, is needed.

Item Description

10.3390/antibiotics13050432
2079-6382