An Easily Overlooked Contamination of Syringes in Newborn Screening by Tandem Mass Spectrometry
Background: Tandem mass spectrometry becomes a common and important test in newborn screening, but potential contamination of the equipment has largely been ignored.Methods: The source of contamination through Biosan quality control samples was examined prospectively, and further confirmed by retros...
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Frontiers Media S.A.,
2021-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_10c5ec1fc4b64f94a04004d51af4d3b8 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yanyun Wang |e author |
| 700 | 1 | 0 | |a Yun Sun |e author |
| 700 | 1 | 0 | |a Tao Jiang |e author |
| 245 | 0 | 0 | |a An Easily Overlooked Contamination of Syringes in Newborn Screening by Tandem Mass Spectrometry |
| 260 | |b Frontiers Media S.A., |c 2021-01-01T00:00:00Z. | ||
| 500 | |a 2296-2360 | ||
| 500 | |a 10.3389/fped.2020.596321 | ||
| 520 | |a Background: Tandem mass spectrometry becomes a common and important test in newborn screening, but potential contamination of the equipment has largely been ignored.Methods: The source of contamination through Biosan quality control samples was examined prospectively, and further confirmed by retrospective analysis of patient samples.Results: We found that the source of contamination came from a syringe in the Biosan quality control samples. Furthermore, we found that a large number of indicators in the patient sample were interfered by syringe contamination in our center, and also in two other newborn screening centers, but the affected indicators were different in different screening centers.Conclusion: Syringe contamination will affect the detection of patient samples by tandem mass spectrometry and should be monitored carefully and immediately. | ||
| 546 | |a EN | ||
| 690 | |a syringe | ||
| 690 | |a contamination | ||
| 690 | |a tandem mass spectrometry (MS/MS) | ||
| 690 | |a quality control (QC) | ||
| 690 | |a newborn screening | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pediatrics, Vol 8 (2021) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fped.2020.596321/full | |
| 787 | 0 | |n https://doaj.org/toc/2296-2360 | |
| 856 | 4 | 1 | |u https://doaj.org/article/10c5ec1fc4b64f94a04004d51af4d3b8 |z Connect to this object online. |