Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity <it>in vivo </it>and <it>in vitro</it>

• Main Authors: Constantin Cristina E (Author), Vogl Christian (Author), Quarta Serena (Author), Üçeyler Nurcan (Author), Sommer Claudia (Author), Kress Michaela (Author)
• Format: Book
• Published: SAGE Publishing, 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Tenderness and mechanical allodynia are key symptoms of malignant tumor, inflammation and neuropathy. The proinflammatory cytokine interleukin-6 (IL-6) is causally involved in all three pathologies. IL-6 not only regulates innate immunity and inflammation but als...