Dopaminergic Hyperactivity Accompanied by Hyperlocomotion in C57BL/6J-bgJ/bgJ (beige-J) Mice
Abstract.: Genetic factors affect locomotor activity, which mainly depends on the activation of dopaminergic systems. C57BL/6J-bgJbgJ (beige-J) mice, which exhibit deficiencies in immunological function, show behavioral hyperactivity. The present study was designed to investigate the locomotor activ...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2014-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Abstract.: Genetic factors affect locomotor activity, which mainly depends on the activation of dopaminergic systems. C57BL/6J-bgJbgJ (beige-J) mice, which exhibit deficiencies in immunological function, show behavioral hyperactivity. The present study was designed to investigate the locomotor activity of beige-J mice accompanied by a change in the dopaminergic system. Beige-J mice showed higher locomotor activity and dopamine turnover, whereas splenectomy reduced this hyperlocomotion and dopamine turnover. These results suggest that beige-J mice could be suitable as an experimental animal model for investigating hyperactivation of the dopaminergic system, and the spleen may contribute to the susceptibility of dopaminergic systems to activation. Keywords:: beige-J mouse, dopamine, splenectomy |
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| Item Description: | 1347-8613 10.1254/jphs.14043SC |