Dopaminergic Hyperactivity Accompanied by Hyperlocomotion in C57BL/6J-bgJ/bgJ (beige-J) Mice
Abstract.: Genetic factors affect locomotor activity, which mainly depends on the activation of dopaminergic systems. C57BL/6J-bgJbgJ (beige-J) mice, which exhibit deficiencies in immunological function, show behavioral hyperactivity. The present study was designed to investigate the locomotor activ...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Elsevier,
2014-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_10ed6d013fce45d1b4f9fd227cd43d2c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Tomohisa Mori |e author |
| 700 | 1 | 0 | |a Masahiko Funada |e author |
| 700 | 1 | 0 | |a Yuko Tsuda |e author |
| 700 | 1 | 0 | |a Jun Maeda |e author |
| 700 | 1 | 0 | |a Masashi Uchida |e author |
| 700 | 1 | 0 | |a Tsutomu Suzuki |e author |
| 245 | 0 | 0 | |a Dopaminergic Hyperactivity Accompanied by Hyperlocomotion in C57BL/6J-bgJ/bgJ (beige-J) Mice |
| 260 | |b Elsevier, |c 2014-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.14043SC | ||
| 520 | |a Abstract.: Genetic factors affect locomotor activity, which mainly depends on the activation of dopaminergic systems. C57BL/6J-bgJbgJ (beige-J) mice, which exhibit deficiencies in immunological function, show behavioral hyperactivity. The present study was designed to investigate the locomotor activity of beige-J mice accompanied by a change in the dopaminergic system. Beige-J mice showed higher locomotor activity and dopamine turnover, whereas splenectomy reduced this hyperlocomotion and dopamine turnover. These results suggest that beige-J mice could be suitable as an experimental animal model for investigating hyperactivation of the dopaminergic system, and the spleen may contribute to the susceptibility of dopaminergic systems to activation. Keywords:: beige-J mouse, dopamine, splenectomy | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 125, Iss 2, Pp 233-236 (2014) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319301471 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/10ed6d013fce45d1b4f9fd227cd43d2c |z Connect to this object online. |