Modified ASO conjugates encapsulated with cytidinyl/cationic lipids exhibit more potent and longer-lasting anti-HCC effects

• Main Authors: Yufei Pan (Author), Jing Guan (Author), Yujing Gao (Author), Yuejie Zhu (Author), Huantong Li (Author), Hua Guo (Author), Qianyi He (Author), Zhu Guan (Author), Zhenjun Yang (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antisense oligonucleotides (ASOs) are a class of therapeutics targeting mRNAs or genes that have attracted much attention. However, effective delivery and optimal accumulation in target tissues in vivo are still challenging issues. CT102 is an ASO that targets IGF1R mRNA and induces cell apoptosis....