A STUDY ON TOPICAL CALCIUM DOBESILATE FOR THE TREATMENT OF LIMITED PLAQUE PSORIASIS
Introduction: Topical dobesilate offers the potential for treatment of plaque psoriasis without atrophy or other local side effects associated with the use of topical corticosteroids. Fibroblast growth factor (FGF)-mediated pathways participate in many of the cellular events implicated in the pathog...
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| Main Authors: | , |
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| Format: | Book |
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Our Dermatology Online,
2013-07-01T00:00:00Z.
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| Summary: | Introduction: Topical dobesilate offers the potential for treatment of plaque psoriasis without atrophy or other local side effects associated with the use of topical corticosteroids. Fibroblast growth factor (FGF)-mediated pathways participate in many of the cellular events implicated in the pathogenesis of psoriasis. Thus, targeting FGF signals may be potentially therapeutic. Aims: To study the efficacy of topical calcium dobesilate for the treatment of 50 patients of limited plaque psoriasis. Methods: For the present study, fifty clinically diagnosed cases of psoriasis with limited number of plaques (<5) were selected from the outpatient dermatology department. Lesions were treated with potassium dobesilate for a maximal period of 4 weeks. No other modality of treatment was used other than emollients and oral antihistaminics. Results: The mean duration of disease in our study was 4.74 + 14.64 years in our study. The mean reduction in PASI score with topical calcium dobesilate was statistically significant in our study (p > 0.05). |
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| Item Description: | 10.7241/ourd.20133.70 2081-9390 |