Endophthalmitis Caused by <i>Bacillus cereus</i>: Clinical Characteristics, Outcomes and Antibiotic Susceptibility
<i>Bacillus cereus</i> endophthalmitis is a severe vision-threatening disease. This study aimed to analyze the clinical characteristics, antibiotic susceptibility, and risk factors for poor final visual acuity (VA) and enucleation or evisceration (ENEV) outcomes of <i>B. cereus<...
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| Main Authors: | , , , , , |
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| Format: | Book |
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MDPI AG,
2024-07-01T00:00:00Z.
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| Summary: | <i>Bacillus cereus</i> endophthalmitis is a severe vision-threatening disease. This study aimed to analyze the clinical characteristics, antibiotic susceptibility, and risk factors for poor final visual acuity (VA) and enucleation or evisceration (ENEV) outcomes of <i>B. cereus</i> endophthalmitis patients. We retrospectively reviewed 52 cases (52 eyes) of culture-proven <i>B. cereus</i> endophthalmitis at Zhongshan Ophthalmic Center from January 2013 to December 2023. The mean age of the patients was 38.1 ± 20.1 years, and males composed the majority (90.4%) of the sample size; laborers (32.7%) and farmers (19.2%) were the primary occupations of the patients. All cases were caused by ocular trauma. Forty-one of 51 eyes (80.4%) had a final VA worse than the ability to count fingers (CFs), and 15 of the 52 total eyes (28.8%) underwent ENEV. Binary logistic forward (LR) regression analysis demonstrated that red eye (odds ratio [OR], 13.13; 95% confidence interval [CI], 1.58-108.80; <i>p</i> = 0.017), eye pain (OR, 22.87; 95% CI, 1.00-522.72; <i>p</i> = 0.050), and corneal edema/ulcer (OR, 13.13; 95% CI, 1.58-108.80; <i>p</i> = 0.017) were significant risk factors for poor VA outcomes. Conjunctival sac purulent discharge (OR, 10.08; 95% CI, 2.11-48.12, <i>p</i> = 0.004) and white blood cell (WBC) count (OR, 1.35; 95% CI, 1.06-1.72, <i>p</i> = 0.016) were significant risk factors for ENEV outcomes. <i>B. cereus</i> showed susceptibility rates of 100.0% to vancomycin and ofloxacin; 98.0% to levofloxacin; 93.3% to ciprofloxacin; 87.5% to imipenem; and 78.9% to tobramycin. The susceptibility to azithromycin and clindamycin was 66.7% and 50.0%, respectively. In contrast, <i>B. cereus</i> was resistant to penicillin (susceptibility at 3.8%), cefuroxime (5.6%), and cefoxitin (37.1%). |
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| Item Description: | 10.3390/antibiotics13070658 2079-6382 |