Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

• Main Authors: Hui Qian (Author), Qingyun Bai (Author), Xiao Yang (Author), Jephte Y. Akakpo (Author), Lili Ji (Author), Li Yang (Author), Thomas Rülicke (Author), Kurt Zatloukal (Author), Hartmut Jaeschke (Author), Hong-Min Ni (Author), Wen-Xing Ding (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) overdose can induce liver injury and is the most frequent cause of acute liver failure in the United States. We investigated the role of p62/SQSTM1 (referred to as p62) in APAP-induced liver injury (AILI) in mice. We found that the hepatic protein levels of p62 dramatically incr...