The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.

Yersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacteriu...

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Main Authors: Guillain Mikaty (Author), Héloïse Coullon (Author), Laurence Fiette (Author), Javier Pizarro-Cerdá (Author), Elisabeth Carniel (Author)
Format: Book
Published: Public Library of Science (PLoS), 2021-10-01T00:00:00Z.
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100 1 0 |a Guillain Mikaty  |e author 
700 1 0 |a Héloïse Coullon  |e author 
700 1 0 |a Laurence Fiette  |e author 
700 1 0 |a Javier Pizarro-Cerdá  |e author 
700 1 0 |a Elisabeth Carniel  |e author 
245 0 0 |a The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages. 
260 |b Public Library of Science (PLoS),   |c 2021-10-01T00:00:00Z. 
500 |a 1935-2727 
500 |a 1935-2735 
500 |a 10.1371/journal.pntd.0009832 
520 |a Yersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacterium to cross and disrupt the endothelial vascular barrier remain poorly understood. In this study, an innovative model of in vivo infection was used to focus on the interaction between Y. pestis and its host vascular system. In the draining lymph nodes and in secondary organs, bacteria provoked the porosity and disruption of blood vessels. An in vitro model of endothelial barrier showed a role in this phenotype for the pYV/pCD1 plasmid that carries a Type Three Secretion System. This work supports that the pYV/pCD1 plasmid is responsible for the powerful tissue invasiveness capacity of the plague bacillus and the hemorrhagic features of plague. 
546 |a EN 
690 |a Arctic medicine. Tropical medicine 
690 |a RC955-962 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009832 (2021) 
787 0 |n https://doi.org/10.1371/journal.pntd.0009832 
787 0 |n https://doaj.org/toc/1935-2727 
787 0 |n https://doaj.org/toc/1935-2735 
856 4 1 |u https://doaj.org/article/123b85de85004b59a08967a8c6e7f4dc  |z Connect to this object online.