Drug screening using model systems: some basics
An increasing number of laboratories that focus on model systems are considering drug screening. Executing a drug screen is complicated enough. But the path for moving initial hits towards the clinic requires a different knowledge base and even a different mindset. In this Editorial I discuss the im...
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| Format: | Book |
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The Company of Biologists,
2016-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | An increasing number of laboratories that focus on model systems are considering drug screening. Executing a drug screen is complicated enough. But the path for moving initial hits towards the clinic requires a different knowledge base and even a different mindset. In this Editorial I discuss the importance of doing some homework before you start screening. 'Lead hits', 'patentable chemical space' and 'druggability' are all concepts worth exploring when deciding which screening path to take. I discuss some of the lessons I learned that may be useful as you navigate the screening matrix. |
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| Item Description: | 1754-8403 1754-8411 10.1242/dmm.028159 |