A Lead Optimization of TOPK Inhibitors Using Complementary Computational and Synthetic Approaches
Background: T-LAK cell-originated protein kinase (TOPK), a member of the MEK3/6-related mitogen-activated protein kinase kinase (MAPKK) family, is highly overexpressed in various cancers. This overexpression is linked to the mitotic phase of the cell cycle, highlighting its potential as a prognostic...
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| Main Authors: | , , , , |
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| Format: | Book |
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Tabriz University of Medical Sciences,
2024-10-01T00:00:00Z.
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