Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging

• Main Authors: Bichun Guo (Author), Sainan Zhang (Author), Shanshan Wang (Author), Huidan Zhang (Author), Junshun Fang (Author), Nannan Kang (Author), Xin Zhen (Author), Yang Zhang (Author), Jidong Zhou (Author), Guijun Yan (Author), Haixiang Sun (Author), Lijun Ding (Author), Chuanming Liu (Author)
• Format: Book
• Published: BMC, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background With advanced maternal age, abnormalities during oocyte meiosis increase significantly. Aneuploidy is an important reason for the reduction in the quality of aged oocytes. However, the molecular mechanism of aneuploidy in aged oocytes is far from understood. Histone acetyltransfe...