Development of T-cell engagers selective for cells co-expressing two antigens

• Main Authors: Danielle M. Dicara (Author), Sunil Bhakta (Author), Mary Ann Go (Author), James Ziai (Author), Ron Firestein (Author), Bill Forrest (Author), Chen Gu (Author), Steven R. Leong (Author), Genee Lee (Author), Shang-Fan Yu (Author), Andrew G. Polson (Author), Nicholas J. Agard (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T cell-engaging bispecific antibodies (TCEs) are clinically effective treatments for hematological cancers. While the utility of TCEs in solid malignancies is being explored, toxicities arising from antigen expression on normal tissues have slowed or halted several clinical trials. Here, we describe...