Phase I crossover study of DNA‐protein kinase inhibitor peposertib in healthy volunteers: Effect of food and pharmacokinetics of an oral suspension

• Main Authors: Andreas Becker (Author), Axel Krebs‐Brown (Author), Claudia Vetter (Author), Tanja Reuter (Author), Almudena Rodriguez‐Gutierrez (Author), Xiaoli You (Author), Michael Lissy (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2023-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Peposertib is an orally administered inhibitor of DNA‐dependent protein kinase. We evaluated the effect of food on its pharmacokinetics, and examined the pharmacokinetics of an oral suspension (OS) of disintegrated tablets, in a phase I, open‐label, crossover three‐period study (NCT04702698...