Leptin-Induced Angiogenesis of EA.Hy926 Endothelial Cells via the Akt and Wnt Signaling Pathways In Vitro and In Vivo

• Main Authors: Fei Yu (Author), Runqing Fu (Author), Lu Liu (Author), Xiaoting Wang (Author), Tingting Wu (Author), Wei Shen (Author), Zhipeng Gui (Author), Xiumei Mo (Author), Bing Fang (Author), Lunguo Xia (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiogenesis involves the activation of endothelial cells followed by capillary formation. Leptin, the protein product of the ob gene, can induce the angiogenic potential of endothelial cells. However, the underlying cellular mechanism still remains to be elicited. We firstly evaluated the in vitro...