Isolation of flavonoids from Anemopaegma arvense (Vell) Stellf. ex de Souza and their antifungal activity against Trichophyton rubrum

• Main Authors: Camila Di Giovane Costanzo (Author), Vanessa Colnaghi Fernandes (Author), Sônia Zingaretti (Author), Rene Oliveira Beleboni (Author), Ana Maria Soares Pereira (Author), Mozart Marins (Author), Sílvia Helena Taleb-Contini (Author), Paulo Sérgio Pereira (Author), Ana Lúcia Fachin (Author)
• Format: Book
• Published: Universidade de São Paulo, 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Anemopaegma arvense (Vell) Stellf. ex de Souza belongs to the family Bignoniaceae, and is popularly known as catuaba. To evaluate the cytotoxic and antimicrobial activity of A. arvense, fraction F3 and flavonoids 1 (quercetin 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside) (rutin) and flavonoid 2 (quercetin 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside) were isolated from the leaves of this plant. Fraction F3 and flavonoids 1 and 2 exhibited no antibacterial activity. Furthermore, no cytotoxic activity of fraction 3 or flavonoids 1 and 2 was observed against the tumor cells tested. However, analysis of the antifungal activity of flavonoids 1 and 2 revealed minimum inhibitory concentrations of 0.5 and 0.25 mg/mL, respectively, against the Trichophyton rubrum strains tested (wild type and mutant). This study demonstrates for the first time the antifungal activity of isolated flavonoids, validating the same activity for A. arvense.

Item Description

2175-9790
10.1590/S1984-82502013000300017