Expression and significance of dendritic cell markers CD123, FXⅢA and CD1a in leprosy lesions
Objective: To explore the role of dendritic cells in the pathogenesis of leprosy. Method: The expression of three dendritic cell markers (CD123, FXⅢA, CD1a) in leprosy lesions was assessed by immunohistochemical staining, and their significance was analyzed. Results: Expression of CD123, FXⅢA and CD...
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| Format: | Book |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology,
2021-02-01T00:00:00Z.
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| Summary: | Objective: To explore the role of dendritic cells in the pathogenesis of leprosy. Method: The expression of three dendritic cell markers (CD123, FXⅢA, CD1a) in leprosy lesions was assessed by immunohistochemical staining, and their significance was analyzed. Results: Expression of CD123, FXⅢA and CD1a was observed in tuberculoid granulomas of paucibacillary leprosy lesion, while lesion of multibacillary leprosy displayed no or minimal expression. Conclusions: CD123, FXⅢA and CD1a positive dendritic cells participate in the cellular immune response in leprosy, and promote the development of the disease toward paucibacillary type. |
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| Item Description: | 1674-8468 10.3969/j.issn.1674-8468.2021.01.005 |