Risk Factors for Carbapenemase-Producing <i>Enterobacterales</i> Infection or Colonization in a Korean Intensive Care Unit: A Case-Control Study

• Asıl Yazarlar: Young Ah Kim (Yazar), Se Ju Lee (Yazar), Yoon Soo Park (Yazar), Yeo Jin Lee (Yazar), Jeong Hwa Yeon (Yazar), Young Hee Seo (Yazar), Kyungwon Lee (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2020-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Özet

The purpose of this study is to identify the factors related to the infection and/or colonization of carbapenemase-producing <i>Enterobacterales</i> (CPE) based on clinical and microbiological data for patients in the intensive care unit (ICU). All patients admitted to medical ICU were screened for CPE on admission and weekly, and this 1:2 case-control study included patients with CPE identified by screening or clinical cultures from 2017 to 2018. The clonal relatedness was evaluated by pulsed-field gel electrophoresis (PFGE). A total of 45 CPE patients were identified with a prevalence of 3.8%. The most frequent organism was <i>Klebsiella pneumoniae</i> (69%) and the carbapenemases belonged to the class A <i>Klebsiella pneumoniae</i> Carbapenemase (KPC-2) (87%), class B New Delhi Metallo-β-lactamase (NDM) (11%), and Imipenemase (IMP-1) (2%) strains. The PFGE profiles showed two large clustered groups of KPC-2-producing <i>K. pneumoniae</i>. In the multivariate analysis, pneumonia/chronic pulmonary disease, previous fluoroquinolone use, and previous use of nasogastric tube were the significant risk factors for CPE infection or colonization in ICU-admitted patients. Critical illness and underlying medical conditions such as pneumonia/chronic pulmonary disease, antimicrobial selective pressure, and the use of a medical device are identified as risk factors for CPE infection or colonization in ICU. Person to person transmission also contributed.

Diğer Bilgileri

10.3390/antibiotics9100680
2079-6382