Myelofibrosis - A less known complication of vitamin D deficiency: A case report with review of literature
Background: Pediatric myelofibrosis is uncommon and is usually secondary to an underlying hematopoietic or nonhematopoietic condition. Among the nonhematopoietic secondary causes, Vitamin D deficiency is an important but rare cause. Clinical Description: An 18-month-old male child with delay in achi...
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| Main Authors: | , , , |
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| Format: | Book |
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Wolters Kluwer Medknow Publications,
2023-01-01T00:00:00Z.
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| Summary: | Background: Pediatric myelofibrosis is uncommon and is usually secondary to an underlying hematopoietic or nonhematopoietic condition. Among the nonhematopoietic secondary causes, Vitamin D deficiency is an important but rare cause. Clinical Description: An 18-month-old male child with delay in achieving milestones for the past 6 months along with anemia and distention of the abdomen for the past 3 months was referred to our institute. Clinical examination revealed global developmental delay with a developmental quotient of 49%, short stature, rachitic features, and massive splenomegaly. Management and Outcome: After ruling out common nutritional and hemolytic causes of anemia, a bone marrow biopsy was done which showed extensive fibrosis, few megakaryocytes, myeloid and erythroid cells with normal maturation, and no storage cells - features consistent with myelofibrosis possibly secondary to Vitamin D deficiency. The clinical and laboratory findings of myelofibrosis improved with Vitamin D therapy and calcium. Conclusion: In developing countries like India, nutritional rickets is highly prevalent. However, rarely such children with rickets may show anemia with extramedullary erythropoiesis. If pediatricians are aware of Vitamin D deficiency-induced secondary myelofibrosis, many unnecessary investigations and work-up for storage diseases can be avoided. The condition is easily reversible with Vitamin D therapy. |
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| Item Description: | 2772-5170 2772-5189 10.4103/ipcares.ipcares_104_23 |