Clinical features and outcomes of Ewing sarcoma in infants: A single center case series from India

• Main Authors: Badira Cheriyalinkal Parambil (Author), Maya Prasad (Author), Venkata Rama Mohan Gollamudi (Author), Ajay Puri (Author), Sajid Qureshi (Author), Siddhartha Laskar (Author), Nehal Khanna (Author), Jifmi Jose Manjali (Author), Mukta Ramadwar (Author), Bharat Rekhi (Author), Vasundhara Patil (Author), Akshay Baheti (Author), Sneha Shah (Author), Girish Chinnaswamy (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: Infantile Ewing Sarcoma (ES) is an extremely rare disease with comparable outcomes on contemporary protocols. There is a paucity of data from India. Methods: Infants with proven ES diagnosed between January 2012 and December 2020 were retrospectively analyzed. The staging was performed using positron emission tomography-computerized tomography scan. Treated infants were administered weight-based chemotherapy. The local control was with surgery and/or radiotherapy. Results: There were 10 infants with ES with a male-to-female ratio of 2.3:1. The majority had extraosseous (90 %, n = 9) or axial primary (50 %, n = 5). Five patients with localized disease received treatment. Two died during induction chemotherapy (sepsis-1, cause unknown-1), and 3 are alive with no evidence of disease at a median follow-up of 8 years (range: 4-9). Two episodes of complicated febrile neutropenia were reported in 5 treated infants. Conclusions: ES in infants is rare and predominantly extraosseous with axial primary. Treated infants with non-metastatic disease tolerated chemotherapy well with good outcomes.

Item Description

2468-1245
10.1016/j.phoj.2024.04.001