Establishment of in vitro Calibration Curve for 60Co-γ-rays Induced Phospho-53BP1 Foci, Rapid Biodosimetry and Initial Triage, and Comparative Evaluations With γH2AX and Cytogenetic Assays

• Hauptverfasser: Rajesh Kumar Chaurasia (Verfasst von), Kapil B. Shirsath (Verfasst von), Utkarsha N. Desai (Verfasst von), Nagesh N. Bhat (Verfasst von), B. K. Sapra (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Schlagworte: article
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A rapid and reliable method for biodosimetry of populations exposed to ionizing radiation in the event of an incident or accident is crucial for initial triage and medical attention. DNA-double strand breaks (DSBs) are indicative of radiation exposure, and DSB-repair proteins (53BP1, γH2AX, ATM, etc...