LC478, a Novel Di-Substituted Adamantyl Derivative, Enhances the Oral Bioavailability of Docetaxel in Rats
P-glycoprotein (P-gp)-mediated efflux of docetaxel in the gastrointestinal tract mainly impedes its oral chemotherapy. Recently, LC478, a novel di-substituted adamantyl derivative, was identified as a non-cytotoxic P-gp inhibitor in vitro. Here, we assessed whether LC478 enhances the oral bioavailab...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2019-03-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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