LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug

• Main Authors: Hyun Ji Kim (Author), Mi Kyung Park (Author), Hyun Jung Byun (Author), Minkyoung Kim (Author), Boram Kim (Author), Lu Yu (Author), Tuan Minh Nguyen (Author), Thi Ha Nguyen (Author), Phuong Anh Do (Author), Eun Ji Kim (Author), Ji Hyun Kim (Author), Enkhmend Enkhtaivan (Author), Kyung Sung Kim (Author), Ji Yun Jang (Author), Gyeoung Jin Kang (Author), Ho Lee (Author), Misun Won (Author), Kyeong Lee (Author), Jungsook Cho (Author), Chang Hoon Lee (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

LW1497 suppresses the expression of the hypoxia-inducing factor (HIF)-1α inhibiting malate dehydrogenase. Although hypoxia and HIF-1α are known to be important in cancer, LW1497 has not been therapeutically applied to cancer yet. Thus, we investigated the effect of LW1497 on the epithelial-mesenchym...